Jamie (Helen Hunt) and Paul Buchman (Paul Reiser) are a young urban couple with five months of marriage behind them and they're still trying to make some ground rules of living together in an apartment in Manhattan. This is definitely not easy because Jamie & Paul are both equally neurotic - but in totally different ways. Paul is a documentary filmmaker, he is charming and creative, but also extremely careful and analytic. Jaime works as a public relations consultant, and is more of a free spirit, but also has a number of discomforts. Jaime's sister Lisa Stemple (Anne Ramsay) often comes to visit them, just like their friends Mark Devanow (Richard Kind), his wife Fran (Leila Kenzle) and Paul's cousin Ira Buchman (John Pankow). But, they aren't the only ones dropping by the apartment - there are always all kinds of other characters like noisy neighbours, a funny dogwalker (Hank Azaria), family members and others.

My Two Dads began airing in the fall of 1987 on NBC Sunday nights at 8pm. The sitcom starred Greg Evigan, who had previous fame from the TV series B.J. and the Bear and Paul Reiser, who later starred in the acclaimed TV comedy, Mad About You. The two played lifelong friends, Joey Harris and Michael Taylor respectively. Rounding out the star cast ensemble was newcomer Staci Keanan in her first ever starring role playing Nicole Bradford, the possible daughter of one of the dads. The show begins when Marcy Bradford (Emma Samms), the mother of Nicole Bradford (Keanan), dies. The two men who had competed for the woman's affections before Nicole was born — Michael Taylor (Reiser) and Joey Harris (Evigan) — are awarded joint custody of Nicole. The mix-ups of two single men raising a teenage daughter provided the story each week. Judge Margaret W. Wilbur (Florence Stanley), a family court judge, would frequently visit the new family and served as Nicole's mentor.