The series will be hosted by astrophysicist Neil de Grasse Tyson and debuts on Fox in 2013. There will be same-night encores on the National Geographic Channel.
"Never more than at this moment in the modern era have we needed a profound reminder of the colossally important and exciting role that science, space exploration and the human quest for knowledge must continue to play in our development as a species," MacFarlane said in a statement. "We should be vigorously exploring the solar system by now, and who better to inspire us to get there than Ann Druyan, Steven Soter, Neil deGrasse Tyson and, of course, Carl Sagan."
"Carl believed that science belongs to all of us," Druyan, Sagan's widow, said in a statement. "He wanted to convey the thrill of its cosmic perspective to the widest possible audience. I wish I could tell Carl what Seth's leadership on this new 'Cosmos' has made possible. Besides, I know how much they would have liked each other."
'Cosmos' first aired in 1980 and has been seen by an estimated 700 million viewers.
Here's how Fox describes the series: "Produced in conjunction with National Geographic Channel, 'Cosmos: A Space-Time Odyssey,' is the story of how human beings began to comprehend the laws of nature and find our place in space and time. By exploring never-before-told stories of the heroic quest for knowledge, the series will take viewers to other worlds and travel across the universe for a vision of the cosmos on the grandest scale. The most profound scientific concepts will be presented with stunning clarity, uniting skepticism and wonder, and weaving rigorous science with the emotional and spiritual into a transcendent experience."