According to TV Guide, Curtis will play Charlotte Ryan, a single mom who works for the Office of the Inspector General in the Defense Department. Look for Curtis to spar with Gibbs (Mark Harmon) and his team.
"Jamie's shoot-from-the-hip style embodies everything we want from [Charlotte Ryan] -- humor, heart, strength and a lot of fun," Gary Glasberg, executive producer of 'NCIS,' said in a statement. "We couldn't be more excited she's here."
Glasberg said they're expecting real chemistry between Curtis' character and Gibbs.
Curtis' last credited guest role on an established series was in a 1996 episode of 'The Drew Carey Show.'
Her last film was 2010's 'You Again' opposite Betty White and Kristen Bell.
This isn't the first time Curtis and Harmon have shared the screen. The two co-starred in the 2003 Disney comedy 'Freaky Friday.'
Curtis' episodes air in November.
'NCIS' returns to CBS on Tues., Sept. 20 at 8PM.