"We're thrilled to welcome Ryan and Brad back to their original home," John Landgraf, president and general manager of FX Networks, said in a statement. "They have shown an uncanny ability to bring original series to the air unlike any that have come before, and to reconcile 'wildly entertaining' with the 'creatively ambitious.'

"Once again, 'American Horror Story' is a wholly unique and original take on its genre with richly drawn characters. The ability to put together a cast of stars such as Dylan McDermott, Connie Britton, Denis O'Hare, Frances Conroy and Oscar-winner Jessica Lange speaks to the quality of the writing and storytelling. This series is going to blow audiences back in their seats, and we can't wait to have it on our air."

'American Horror Story' follows the Harmon family just after their move from Boston to Los Angeles. McDermott plays Ben Harmon a psychiatrist and Britton plays his wife Vivien. Lange, in her first series regular TV work, plays Constance, the Harmons' neighbor.

The series has been picked up for 13-episodes and will premiere in October. Murphy and Falchuck wrote the pilot script and will serve as executive producers.

"Brad and I are excited to be back at FX where we enjoyed such a terrific relationship working with John Landgraf and his team through 100 episodes of 'Nip/Tuck,'" Murphy said in a statement. "The support of John, Dana Walden and Gary Newman on American Horror Story has been nothing short of amazing. Our cast is extraordinary and we can't wait to get started on production."