Gillan, who will return with Matt Smith to the hit series in 2012, said she doesn't want to make any return cameos after her time as the Doctor's companion is up.
"Death would be an option," Gillan said. "I don't want Amy to pop up again every so often, because for me it would take away from the big, emotional goodbye."
'Doctor Who' is approaching a milestone 50th anniversary in 2013, with many speculating that the season will be the last for current stars Gillan and Smith. The Doctor's recent previous companions Rose Tyler (Billie Piper), Donna Noble (Catherine Tate) and Martha Jones (Freema Agyeman) have all made cameos after departing the TARDIS.
"Once she's gone, she's gone," Gillan said. "I want people to remember the Amy Pond era as a good one."