But despite this bevvy of projects he currently has on the air and in development, we can't shake the feeling that the final frontier of MacFarlane's quest to take over your TV could put him in front of the cameras, not behind them. Is it possible he might be TV's next late-night talk show host? He's got the good looks of on-camera talent, his Twitter feed is filled with jokes about politics and current events, and pretty much everything he's touched has turned successful.
Read on for our theory about why MacFarlane would make a great late-night host, and why we think it could actually become a reality.
MacFarlane has had a very prominent, and prolific, foray into hosting at the Comedy Central Roasts, where he's thrived as Roast Master in a raunchy, fast-paced environment perfectly suited to his skills. The last two insult-fests of David Hasselhoff and Donald Trump were the highest-rated roasts yet, and MacFarlane is reprising his role for the Sheen extravaganza, which promises to be even more outrageously entertaining, and highly-rated, than any we've seen to date.
Then there was MacFarlane's surprise, under-the-radar guest-hosting gig on the Internet-only Overtime segment on the season finale of 'Real Time With Bill Maher,' which really piqued our interest. The segment had the feel of some sort of try-out: MacFarlane seemed uncharacteristically nervous, explaining Maher's absence by saying "Bill had to go fight crime." HBO declined to clarify the details of MacFarlane's guest-spot, but watching it, we couldn't help but wonder if they might be considering developing a talk-show around his talents.
Another unique asset MacFarlane could bring to the table are his skills as a song & dance man. Yes, he's got an orchestral/big band album of '40s & '50s songs called 'Music is Better Than Words' coming out soon, and a concert special featuring himself and Sarah Bareilles airing on Sept. 24 on EPIX. Could musical comedy bits work on late-night TV? Jimmy Fallon's in-character performances, like his epic 'Party in the USA' cover with David Crosby and Graham Nash, have proved that there's actually a big viral market for this type of content.
So we've laid out why we think MacFarlane could make an excellent late-night host. But where could his show land? MacFarlane is extremely well-connected at Fox, where they've been rumored to be interested in diving into the late-night game for years. He's also had huge success on Comedy Central, and we have a hunch HBO might be interested as well. Those three possible landing spots could make a lot of sense.
Then there's the question of whether MacFarlane has the time, between his myriad of projects, to host a nightly or weekly show. Would juggling all of those gigs even be humanly possible? Probably not, but we'd like to see MacFarlane try.
Gallery: Seth MacFarlane Through the Years
Tell us: Would you like to see Seth MacFarlane as a late-night TV host?