According to Deadline, Rhea Perlman will co-star opposite Alley on 'The Manzanis.'
The new show sees Alley star as Angela Manzani, a very opinionated mother whose family clashes with their new neighbors. Perlman will play Angela's mother-in-law, Camille Manzani.
After 'Cheers' Perlman and Alley shared the screen one other time, in an episode of Alley's Showtime series 'Fat Actress.'
Sitcom veterans Marco Pennette and Dave Flebotte are writing the project.
'The Manzanis' has been described as a modern twist on 'Roseanne.'